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According to Dr. Jacob Selhub and colleagues in the American Journal of Clinical Nutrition, "the status of these vitamins is frequently inadequate in the elderly and recent studies have shown associations between loss of cognitive function or Alzheimer's disease and inadequate B vitamin status."
Research has shown that an inadequate B vitamin status may result in neurocognitive dysfunction through elevated homocysteine concentrations in the blood, or hyperhomocysteinemia. Homocysteine is an amino acid that is produced in the human body. Prevalent in the elderly population, hyperhomocysteinemia is largely attributed to insufficient levels of folic acid and vitamins B6 and B12.
The association between cognitive dysfunction and hyperhomocysteinemia has been demonstrated in numerous studies. For instance, Dr. Selhub and colleagues reported that "patients with Alzheimer's disease had higher total plasma homocysteine concentrations than did age-matched healthy controls," while "elderly patients with depression who had lower cognitive screening test scores had significantly higher homocysteine concentrations than did patients with normal cognitive screening tests."
Because folic acid and vitamins B6 and B12 are often deficient among many elderly patients, the importance of these vitamins in the prevention of hyperhomocysteinemia and neurocognitive dysfunction cannot be overlooked.
Am J Clin Nutr 2000;71(2):6145-205.
Advanced Nutrition Publications ©2002